7. EPMO Open Source Coordination Office Redaction File Detail Report

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7.1 Files compared

#	Location	File	Last Modified
1	Genisis_v3.zip\Release 3_Docs	Genisis2_Section_508_Project_Description_06162017.docx	Wed Jun 28 20:38:10 2017 UTC
2	Genisis_v3.zip\Release 3_Docs	Genisis2_Section_508_Project_Description_06162017.docx	Wed Jul 12 18:19:55 2017 UTC

7.2 Comparison summary

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7.3 Comparison options

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7.5 Comparison detail

	1	The Depart ment of Ve terans Aff airs (VA) has establ ished lead ership in genomic me dicine thr ough the u ndertaking of a grou nd-breakin g program called the Million V eteran Pro gram (MVP) . Launched in 2011, MVP invite s users of the VA he althcare s ystem nati onwide to participat e in a lon gitudinal study with the aim o f better u nderstandi ng the int er-relatio n of genet ic charact eristics, behaviors and enviro nmental fa ctors, and Veteran’s health. T oday, with over 500, 000 partic ipants and recruitin g at 50 VA sites nat ionally, M VP is the largest ge nomic rese arch datab ase in the world. Th e MVP data consists of blood s amples fro m consenti ng Veteran s that is used to ge nerate gen omic data, data from questionn aires and the electr onic healt h record d ata. This resource i s made ava ilable to VA researc hers and V A-approved affiliate s to pursu e genomic discoverie s and vali dation stu dies that can lead t o personal ized healt hcare for Veterans. Ultimately , over the long term , validate d scientif ic finding s will be returned t o the Vete ran and in corporated into thei r medical record to fulfill th e potentia l of perso nalized me dicine – d elivery of optimal i nterventio ns to pati ents based on their biological character istics.
	2	The primar y componen t of the p roject is the Genomi c Informat ion System for Integ rative Sci ence (Geni sis) platf orm. Genis is 1.0, im plemented over a fou r-year per iod (2011 - 2015), f eatures a series of modular ap plications to facili tate recru itment and enrollmen t of MVP p articipant s, automat ing most s tudy-relat ed logisti cs includi ng study e nrollment, clinical study data capture, consent, b lood sampl e tracking , and geno mic data s torage. Ge nisis 1.0 also provi des the se cure analy tical infr astructure necessary to conduc t robust g enomic and bioinform atics-rela ted data m anagement and data a nalysis. T his remote ly accessi ble analys is environ ment featu res a high - performa nce comput ing cluste r with sig nificant s torage cap acity and tools for scientific analysis of combine d genotypi c and phen otypic dat a.
	3	This proje ct, Genisi s2 Technic al Service s, provide s addition al functio nality to the Genisi s 1.0 plat form by au tomating d ata proces sing, data request t ransaction s, and dat a request tracking f or integra ting VA In formatics and Comput ing Infras tructure ( VINCI) cli nical data into Geni sis2, as w ell as pro viding enh anced syst em adminis tration. Additional informati on is avai lable in t he Master Test Plan that suppo rts Genisi s2 Build 3 .