popHealth® is an Open-Source Clinical Quality Measure database and reporting engine with data presented through a web-based interface. It includes a centralized repository of clinical data. Data is sent from EHRs via nationally recognized standards such as Consolidated Clinical Data Architecture (C-CDA) Continuity of Care (CCD) Documents or QRDA (Quality Reporting Data Architecture) Cat 1 Documents. Clinical Quality Measures (CQMs) are calculated for providers and presented through a web-based interface with drill down ability to the provider and patient-level data. It allows providers to track trends in quality and health over time and calculate CQMs for Meaningful Use and other CQM Reporting. popHealth® leverages the Cypress validation capability, references measure bundles from the NIH, and supports use of custom defined measures that are generated by an organization with MAT/Bonnie. popHealth® can be integrated with systems supporting practices of various sizes and government entities.