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1 | RAMS-2.3.0.zip\RAMS-2.3.0\OnlineHelp\ACORP | ACORP_App4Instructions.docx | Thu May 17 00:41:02 2018 UTC |
2 | RAMS-2.3.0.zip\RAMS-2.3.0\OnlineHelp\ACORP | ACORP_App4Instructions.docx | Tue Jul 17 21:20:00 2018 UTC |
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1 | Instructio ns for Com pletion of the | |
2 | ACORP Appe ndix 4 – A NTEMORTEM SPECIMEN C OLLECTION | |
3 | (ACORP App . 4 Instru ctions) | |
4 | Version 4 | |
5 | ||
6 | These inst ructions p rovide det ailed guid ance on co mpleting A ppendix 4 of the ACO RP, and ar e referenc ed to the numbers of the items in Append ix 4. ONLY complete this appen dix if it is relevan t to the p rotocol be ing submit ted for re view. The PI may use the ACORP Appendix 4 template provided in the RAM S applicat ion by usi ng the lin k availabl e in quest ion 12 of section M. | |
7 | ||
8 | General In structions : | |
9 | Answer eac h question by comple ting the t able provi ded or ent ering the requested informatio n at the ► . Enter “N /A” for an y item tha t does not apply to this proto col. The sections o f the form will expa nd as need ed. | |
10 | To check a n item, ty pe “X” ins ide the ( ) provid ed. | |
11 | Define eac h abbrevia tion the f irst time it is used . | |
12 | ||
13 | Header for Every Pag e. The he ader infor mation for this appe ndix is pr e-populate d to match header fo r the Main Body of t he ACORP t o which it applies, to identif y each pag e of this Appendix w ith that A CORP: | |
14 | PI’s last name: The PI’s name is prepopu lated | |
15 | Protocol N o. Assigne d by the I ACUC – Thi s is a uni que identi fier for e ach protoc ol that is automatic ally gener ated by th e system t o the prot ocol as a whole | |
16 | ||
17 | Official D ate of App roval – Th is is the date of fi nal and un equivocal approval b y the IACU C, as defi ned in the PHS Assur ance, whic h determin es the due dates of the first annual con tinuing re view and t he trienni al de novo review, a s applicab le. The IA CUC commit tee will e nter this date into the form w hen a deci sion is ma de. | |
18 | ||
19 | ||
20 | Summary. Include in this Appe ndix each body fluid , tissue, or device that is li sted in It em R of th e main bod y of the A CORP and m arked in t he last co lumn of It em R as “O ther colle ction”. P ost-mortem collectio n, blood c ollection associated with anti body produ ction (det ailed in A ppendix 2) , and coll ections th at are par t of the s urgical pr ocedures d etailed in Appendix 5, need no t be inclu ded here. | |
21 | ||
22 | Remember t hat the pr ocedure(s) for each collection listed he re should be describ ed in Item C of the main body of the ACO RP (includ ing how th e instrume nts will b e steriliz ed and the method of hemostasi s to be us ed). | |
23 | ||
24 | Indicate “ yes” under “Anesthes ia” if any measures will be ta ken to pre vent pain or distres s during c ollection of the spe cimens (in cluding bo th adminis tration of pharmacol ogical ane sthetics, analgesics , or tranq uilizers, and use of non-pharm acologic m ethods suc h as cooli ng). | |
25 | ||
26 | For the “A mount Coll ected”, en ter the fo llowing: | |
27 | ||
28 | For fluids , enter th e volume ( ml). For blood samp les, also give the % of total blood volu me represe nted by ea ch sample (total blo od volume may be est imated for rodents a nd rabbits as 6% of lean body mass). As sume that 1 ml of bl ood weighs 1 gram. | |
29 | For any ta il snips t hat will n ot be docu mented as surgical p rocedures in Appendi x 5, enter here the length of tail to be removed ( mm). | |
30 | For other solid tiss ues, enter the mass (g) or vol ume (ml).. | |
31 | ||
32 | For “Volum e Replacem ent”, ente r “N/A” fo r samples of solid t issues. E nter “yes” or “no” f or each fl uid specim en collect ed. | |
33 | ||
34 | Use of Ane sthetics, Tranquiliz ers, or An algesics. | |
35 | For collec tion of sp ecimens wi thout appl ication of any measu res to pre vent pain or distres s, provide details o f why such measures are not ap propriate for this p rotocol, a nd describ e how the animals wi ll be rest rained, if necessary . | |
36 | For collec tion of sp ecimens th at involve s applicat ion of mea sures to p revent pai n or distr ess, descr ibe the me asures to be taken. Any agents that will be admini stered sho uld be inc luded in A ppendix 3. | |
37 | ||
38 | Volume Rep lacement f or Fluid C ollections . | |
39 | ||
40 | For collec tion of fl uid sample s WITHOUT replacemen t of fluid volume, e xplain why the volum e will not be replac ed (give t he calcula tions that show that the volum es removed are so sm all that r eplacement is not ne cessary, p rovide the scientifi c reasons, etc.). | |
41 | ||
42 | For collec tion of fl uid sample s WITH rep lacement o f the remo ved volume s, describ e the repl acements t hat will b e provided (their co mposition, volume, a nd route o f administ ration). B e sure to include th e replacem ent fluids in Append ix 3. | |
43 | ||
44 | Monitoring the anima ls. The a nimals mus t be monit ored after each coll ection of specimens to ensure that they recover ap propriatel y. Includ e the meth ods of mon itoring to be used, and how lo ng the ani mals will be monitor ed specifi cally for recovery f rom specim en collect ion. Desc ribe the c riteria th at will be considere d indicato rs of the need for i nterventio n, and des cribe the correspond ing interv entions to be made ( e.g., admi nistration of analge sics, appl ication of pressure, euthanasi a). |
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