Forward and Reverse Monograph

A single VA Custom Drug-Drug Interaction could be associated with a separate custom Professional Monograph for the forward and reverse interactions. An interaction described as Drug A and Drug B would have a different Custom Monograph from an interaction described as Drug B and Drug A. These different monographs may be necessary because there could be a different Clinical Effect Code between forward and reverse interactions (DrugA+DrugB: Clinical Effect Code = Adverse effects of the former drug; DrugB+DrugA: Clinical Effect Code = Adverse effects of the latter drug).

The following VA Custom Professional Monograph pairs will be associated with each other. This means that when a Monograph is assigned to a VA Custom Drug-Drug Interaction, the corresponding Monograph will be automatically assigned to the reverse Drug-Drug Interaction (DDI1 = DrugA + DrugB; DDI2 = DrugB+DrugA).

Monograph ID and Title Paired Monograph ID and Title

150022 VA Customized: Adverse Effects of Former Drug (Critical) (ARF1) 150024 VA Customized: Adverse Effects of Latter Drug (Critical) (ARL1)
150023 VA Customized: Adverse Effects of the Former Drug (Significant) (ARF2) 150025 VA Customized: Adverse Effects of the Latter Drug (Significant) (ARL2)
150030 VA Customized: Decreased Effects (Critical) (DEF1) 150032 VA Customized: Decreased Effects (Critical) (DEL1)
150031 VA Customized: Decreased Effects (Significant) (DEF2) 150033 VA Customized: Decreased Effects (Significant) (DEL2)
150034 VA Customized: Increased Effects (Critical) (INF1) 150036 VA Customized: Increased Effects (Critical) (INL1)
150035 VA Customized: Increased Effects (Significant) (INF2) 150037 VA Customized: Increased Effects (Significant) (INL2)
150040 VA Customized: Mixed Effects of Former Drug (Critical) (MXF1) 150103 VA Customized: Mixed Effects of Latter Drug (Critical) (MXL1)
150041 VA Customized: Mixed Effects of the Former Drug (Significant) (MXF2) 150104 VA Customized: Mixed Effects of the LatterDrug (Significant) (MXL2)

When viewing a Drug-Drug Interaction, the PECS user interface will only display the Professional Monograph associated with the Forward interaction. The associated Reverse Professional Monograph will only be visible in the custom updates file created by the Release Manager.

Custom Update Sections with Forward/Reverse Monographs