The drug pairs that are associated with a Drug-Drug Interaction (DDI) need to go through the approval/state change process themselves (be approved, rejected, modified, or deleted), separately from the DDI. If the drug pairs are acted upon at the same time as the DDI is acted upon, there is no problem in an Approver knowing that the drug pair needs to be acted upon. However, drug pairs may be added or modified even after a DDI has been acted upon. The way an Approver will know if they need to act on a drug pair associated with an already-approved DDI is by the row on the home page tables that displays the row “Approved Drug-Drug Interaction with Pending Drug Pairs.
screen shot pending
In the screen above, if you select the link "My Assigned Drug Pairs Associated with Approved Drug-Drug Interactions" for one of the states listed, you are taken to the Advanced Query/Customization page that displays the results for all Drug-Drug Interactions with associated Drug Pairs assigned to you in that state. Here you can act on the drug pairs.
If you change the state of the drug pairs to Submit as Reviewed or Submit for Delete, the drug pairs are automatically reassigned to the "Unassigned" User ID. [need add'l info]
New drug pairs are by default assigned to the same User ID as the associated DDI, but an Approver can reassign the drug pairs. When you are working with the Drug Pair customization window, There is a drop-down where you can assign the request to a user ID. The default is the Approver who is assigned to the DDI, but you can change that. [need add'l info]